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BTL NEDERLAND

STRATEGIC SOLUTIONS FOR CHEMISTRY

Insights

May 2024 - January 2025, volume 8 – number 1

● Article:

Atef Sobhy Iskander

● Insights into Centrosomes and The Implications of Their Aberration in Human Diseases

Insights, May 2024 - January 2025, Volume 8, Issue 1, 2-34.

Centrosome is a complex organelle that serves as a microtubule organizing centre, and is involved in several cellular process including mitotic spindle assembly, cell cycle progression, neurogenesis, cell polarity and migration. Thus, centrosomal abnormalities lead to a variety of diseases and disorders ranging from neurodegenerative diseases, developmental disorder to cancer. The objective of this study is to identify new hypothetical therapeutic strategies, which can be considered as a platform for exploring new ideas to overcome centrosome instability and its implication in human diseases. To realize such a goal, a brief general survey is introduced to gain a better understanding of how the roles of centrosome play in cell cycle and checkpoint signaling; how the structure and function of centrosomal-associated proteins orchestrate cell division and what are the consequences of their overexpression that impact centrosome stability, which can lead to centrosome amplification and tumor malignancy. Finally, some new proposed therapeutic interventions are introduced, which may be useful to screen novel strategies to overcome the consequences of centrosome instability.

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