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BTL NEDERLAND

STRATEGIC SOLUTIONS FOR CHEMISTRY

Insights

December 2023 - April 2024, volume 7 – number 1

● Article:

Atef Sobhy Iskander

● The Tetrafluoro-λ6-sulfanyl Compounds: Highlight

Insights, December 2023 - April 2024, Volume 7, Issue 1, 3-20.

In the field of fluorination, various fluorinated reagents have been demonstrated, which elegantly exploit their adaptive characteristics. In this context, the trans-tetrafluoro-λ6-sulfanyl (trans-SF4) moiety is envisioned to be the building blocks of the next generation of bioactive molecules. The trans-SF4-contianing molecules owing to their characteristic structural and chemical properties could serve as a promising alternative of conventional bioisosteres. Furthermore, the trans-trifluoromethyl tetrafluorosulfanyl (trans-SF4CF3) moiety is a unique group for the incorporation into organic molecules due to their strong electron-withdrawing and steric effects, which strongly influence the reactivity of any molecule into which it is substituted. This highlight focuses on the recent development in the synthetic methodologies and applications of these groups, illustrating their interesting potential in the field of bioactive compounds. This highlight is anticipated to stimulate eclectic ideas toward further development in this area in drug design and beyond.

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